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The interactions of p62 as well as UPS, autophagy and ubiquitinated proteins. On UPS inhibition, p62 is upregulated and phosphorylated on S405 and S409, that may aid the degradation of ubiquitinated cargoes by using autophagy. p62 synthesis is induced by a rise in Nrf2 next UPS deficiency. The amplified p62 competes with Nrf2 for Keap1, and after t